| Company | Industry | # Emp | HQ | Company Total Emp | Additional Information |
| SCHOOL BOARD LAFAYETTE PARISH | Education | 4250 | - | - | |
| LAFAYETTE CONSOLIDATED GOVERNMENT | Public Administration | 2008 | - | - | Includes all government offices EXCEPT Clerk of Court, Assessor, and Sherriff |
| UNIV OF LA LAFAYETTE | Education | 1900 | - | - | |
| LAFAYETTE GENERAL MEDICAL CTR | Healthcare | 1757 | - | - | Includes hospital, imaging, and surgical centers |
| WAL-MART STORES INC. | Retail Trade | 1664 | - | - | Includes Wal-Mart and Sam's Club locations |
| ISLAND OPERATING COMPANY | Oil and Gas | 1500 | HQ | - | |
| STULLER INC. | Manufacturing | 1471 | HQ | - | |
| HALLIBURTON ENERGY SVC | Oil and Gas | 1371 | - | - | Locations within parish |
| OUR LADY OF LOURDES REG MED CT | Healthcare | 1310 | - | - | Includes hospital and affiliated services |
| CINGULAR WIRELESS | Telecommunications | 1150 | - | - | Only includes the call center |
| UNIVERSITY MEDICAL CTR | Healthcare | 1000 | - | - | Includes hospital and affiliated services |
| OMNI ENERGY SERVICES, CORP | Oil and Gas | 950+ | HQ | - | Locations withing parish |
| MAC-LAFF INC. | Service | 950 | - | - | McDonald's locations within parish |
| MONCLA WELL SERVICE INC. | Oil and Gas | 849 | - | - | Locations within parish |
| ACADIAN AMBULANCE & AIR MED SERVICES INC. | Healthcare/Transportation | 835 | HQ | 2483 | |
| ESS SUPPORT SERVICES WORLDWIDE | Retail Trade | 831 | - | - | Locations within parish |
| THE ACE GROUP | Transportation | 652 | HQ | 2250 | |
| FRANK'S CASING CREW | Oil and Gas | 625 | - | - | |
| WOMEN'S & CHILDREN'S HOSPITAL | Healthcare | 610 | - | - | Includes hospital and affiliated services |
| LAFAYETTE PARISH GOVERNMENT (not a part of LCG) | Public Administration | 597 | - | - | Includes Clerk of Court, Assessor, and Sherriff's Ofices |
| ALBERTSON'S FOOD & DRUG | Grocery | 582 | - | - | Locations within parish |
| CHEVRON USA PRODUCTION CO | Oil and Gas | 569 | - | - | Locations within parish |
| PETROLEUM HELICOPTERS INC | Transportation | 555 | HQ | 2253 | |
| FUGRO | Oil and Gas | 550 | - | - | Includes, Fugro Chance Inc., Geoservices, and Land Surveys |
| US POST OFFICE | Public Administration | 487 | - | - | Locations within parish |
| NUCOMM INTERNATIONAL | Telecommunications | 465 | - | - | Call Center |
| BAKER HUGHES INTEQ | Oil and Gas | 465 | - | - | |
| MEDICAL CENTER-SW LA | Healthcare | 460 | - | - | Includes hospital and affiliated services |
| ANADRILL SCHLUMBERGER | Oil and Gas | 455 | - | - | |
| LHC GROUP | Healthcare | 451 | HQ | 4357 | Locations within parish |
| TAYLOR'S INTERNATIONAL SERVICES | Food Service | 400 | HQ | - | Has locations on 4 continents |
| LOWE'S | Retail Trade | 375 | - | - | Locations within parish |
| ARIES MARINE | Oil and Gas | 350 | HQ | - | |
| OSCA-BJ SVC | Oil and Gas | 328 | - | - | Locations within parish |
| HILTON LAFAYETTE AND TOWERS | Hospitality | 321 | - | - | |
| ROTOCRAFT LEASING, LLC | Leasing Service | 320 | - | - | Locations within parish |
| GANNETT CO. INC. | Communication | 302 | - | - | |
| COX COMMUNICATIONS | Communications | 300+ | - | - | Includes call center and service representatives |
| MORENO GROUP, LLC | Oil and Gas | 300 | HQ | 1500 | Locations within parish |
| KERGAN BROTHERS | Retail Trade | 300 | HQ | 1500 | Includes Kergan Investments and all Sonic Drive-In locations in Parish |
| C&C TECHNOLOGIES | Oil and Gas | 296 | HQ | 400+ | |
| BORDEN'S INC. | Wholesale Trade | 294 | - | - | |
| C.H. FENSTERMAKER AND ASSOCIATES INC. | Engineering | 290 | - | - | |
| SLEMCO | Utility Provider | 270 | - | - | Locations within parish |
| DOERLE FOOD SERVICES, INC | Wholesale Trade | 261 | HQ | 301 | |
| SYDRAN | Service | 259 | - | - | Burger King locations within parish |
| IBERIA BANK | Finance | 257 | HQ | 708 | Locations within parish |
| SCHUMACHER GROUP OF DELAWARE, INC., THE | Healthcare | 255 | HQ | - | Has locations in 17 states |
| HOME DEPOT | Retail Trade | 245 | - | - | Locations within parish |
| SUPERIOR ENERGY SERVICES INC | Oil and Gas | 245 | - | - | Includes locations within parish EXCEPT affiliated companies |
| GULF COAST TEACHING FAMILY SERVICES | Social Service | 242 | - | - | |
| WEATHERFORD | Oil and Gas | 240 | - | - | Locations within parish and affiliates; Unavailable for 2008 updates |
| MEADOW BROOK SPECIALTY HOSPITAL | Healthcare | 237 | - | - | |
| TMC FOODS | Service | 225 | HQ | 600 | Popeye's Chicken and Biscuits locations within parish |
| STONE ENERGY CORPORATION | Oil and Gas | 225 | - | - | |
| RED LERILLE'S HEALTH AND RACQUET | Recreation | 225 | - | - | |
| BRINKER INTERNATIONAL | Service | 223 | - | - | Chili's locations within parish |
| MIDSOUTH BANK | Finance | 223 | - | - | Locations within parish |
| NACHER CORPORATION | Oil and Gas | 212 | - | - | |
| BERNHARD MECHANICAL CONTRACTORS INC. | Construction | 200 | - | - | |
| HEART HOSPITAL OF LAFAYETTE | Healthcare | 200 | - | - | Includes hospital and affiliated services |
| DUPRE TRANSPORT LLC | Transportation | 200 | HQ | - | |
| ABERCROMBIE & FITCH CO. | Retail Trade | 196 | - | - | Includes Abercrombie & Fitch, Abercrombie Kids, and Hollister Co. |
| ACADIANA BOTTLING CO. INC.& ACADIANA VENDING SERVICES | Wholesale Trade | 195 | - | - | |
| DOUG ASHY BUILDING MATERIALS, INC | Retail Trade | 192 | - | - | Locations within parish |
| DELMAR SYSTEMS, INC. | Oil and Gas | 189 | HQ | 240 | |
| REPUBLIC BEVERAGE | Wholesale Trade | 188 | - | - | |
| GILES AUTOMOTIVE | Retail Trade | 177 | - | - | |
| BEST WESTERN - HOTEL ACADIANA | Hospitality | 175 | - | - | |
| SCHILLING DISTRIBUTING CO. INC. | Wholesale Trade | 174 | - | - | |
| CVS PHARMACY | Retail Trade | 170 | - | - | Locations within parish |
| LAFAYETTE COCA-COLA BOTTLING | Wholesale Trade | 168 | - | - | |
| WALGREEN'S | Retail Trade | 163 | - | - | Locations within parish |
| SERVICE CHEVROLET INC. | Retail Trade | 161 | - | - | |
| UNITED PARCEL SERVICE | Courier Service | 161 | - | - | Includes distribution and retail locations within parish; unavailable for 2008 updates |
| HUB CITY FORD INC. | Retail Trade | 150 | - | - | |
| COMPLETE HOME HEALTH | Healthcare | 150 | - | - | |
| CHASE | Finance | 147 | - | - | Locations within parish |
| GAP INC. | Retail Trade | 140 | - | - | Includes Gap, Gap Kids, Baby Gap, Old Navy, and Banana Republic |
| SOUTHERN THEATRES | Entertainment | 140 | - | - | The Grand locations within the parish |
| MOSS MOTORS INC. | Retail Trade | 135 | - | - | |
| MANN COMPANIES | Retail Trade | 133 | - | - | Includes Saturn of Acadiana and LA Motors |
| CINTAS | Distribution | 133 | - | - | |
| THE LEMOINE CO. LLC | Contracting Services | 130 | - | - | |
| LOUISIANA VALVE SOURCE | Oil and Gas | 129 | - | - | |
| AMERICA'S PIZZA CO. LLC | Service | 126 | - | - | Pizza Hut locations within parish |
| INTERNATIONAL PAPER | Manufacturing | 124 | - | - | |
| WPS INC. | Oil and Gas | 120 | - | - | Locations within parish |
| ACME TRUCk LINE INC | Transportation | 120 | - | - | Includes drivers and personnel in parish |
| DC INTERNATIONAL | Oil and Gas | 116 | HQ | - | |
| MACRO OIL CO. INC. | Oil and Gas | 108 | - | - | Locations within parish |
| GLAZER | Wholesale Trade | 106 | - | - | |
| KNIGHT OIL TOOLS, INC | Oil and Gas | 100+ | HQ | 700+ | Locations within parish |
| FEDEX | Courier Service | 100+ | - | - | Locations within parish |
| CAPITAL ONE BANK | Finance | 100+ | - | - | Locations within parish; based on industry employment norms |
| CC'S COFFEE | Retail Trade | 100 | - | - | Locations within parish |